Lactate is the end product of anaerobic metabolism. Lactate is generated mainly in skeletal muscle, brain, erythrocytes, the skin and the gut and is disposed of by gluconeogenesis in the liver and by complete oxidation. Lactic acidosis can be due to excessive lactate formation or decreased removal.
As an important metabolic substrate, lactate is an intercellular and inter-tissue redox signaling molecule that provides energy for oxidative metabolism in many tissues and helps maintain redox
Lactate is mainly metabolised by the liver and partially by myocytes, though the kidney plays more of a role in metabolism in the presence of hyperlactataemia. Hyperlactataemia Hyperlactataemia reflects an imbalance between production and clearance of lactate.
Lactic acid is a chemical your body produces when your cells break down carbohydrates for energy. You might see it referred to as lactate. Muscle cells and red blood cells make the most lactic acid, but it can come from any tissue in your body. Most people think of lactic acid in their muscles during a tough workout. Cite Share Subject Physiology - Other Issue Section: Articles Key points Blood lactate concentrations reflect the balance between lactate production and clearance. Glycolysis, gluconeogenesis and pyruvate conversion to and from lactate are linked with NAD + and NADH. Lactate is one of the substances produced by cells as the body turns food into energy (cell metabolism), with the highest level of production occurring in the muscles. Depending on pH, it is sometimes present in the form of lactic acid.
Lactate is a key energy substrate in skeletal muscle fibers, providing us with sufficient energy during exercise. Lactate increases the number of mitochondria (the energy powerhouses of cells) in muscle cells. Lactate plays a key role in supplying energy for cognitive functioning during exercise.
The levels of blood lactate and fibrinogen may represent the severity of children with traumatic brain injury and may be risk factors for poor prognosis of children with traumatic brain injury. Traumatic brain injury (TBI) is a significant cause of morbidity and mortality in pediatric patients, leading to long-term physical, cognitive, and
Lactate is the ionic (electrically charged) form of lactic acid. It is produced by muscle cells, red blood cells, brain, and other tissues during anaerobic (oxygen deficient) energy production and is usually present at low concentrations in the blood. Aerobic energy production is the body's preferred process, but it requires an See More .
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    • what is lactate in blood